Group members

Ingrid Verhaart, PhD

Dr. Ingrid Verhaart is a postdoctoral fellow in the DMD Genetic Therapy Group. She studied Biomedical Sciences at the Leiden University from 2004 to 2009. During her PhD at the department of Human Genetics of the Leiden University Medical Center (LUMC) under supervision of prof. dr. Gertjan van Ommen and dr. Annemieke Aartsma-Rus she worked on the pre-clinical optimization of antisense oligonucleotide (AON) mediated exon skipping for Duchenne muscular dystrophy (DMD). In May 2014 she defended her thesis titled: “Optimising antisense oligonucleotide-mediated exon skipping for Duchenne muscular dystrophy”. Thereafter she has worked at the Newcastle University on spinal muscular atrophy (SMA), DMD and muscular dystrophy type 1 (DM1). In February 2018 she returned to the DMD genetic therapy group. She is currently involved in the validation lab, which aims to evaluate compounds that may be of benefit to Duchenne patients in preclinical DMD animal models. Next to her work in the validation lab, she also works for the Duchenne Parent Project (DPP)/World Duchenne Organization (WDO). Ingrid has authored 14 articles, of which 8 as a first author, and a book chapter.

Click here to see the publication list of dr. Ingrid Verhaart

Group members

Silvana Jirka, BASc.

Silvana Jirka is a PhD-student in the DMD Genetic Therapy Group. She started her PhD in January 2012 under the supervision of Dr A.a.Aartsma-Rus and her promotor is Proffessor Dr. G.J. van Ommen. During here PhD she will focus on the optimization of the antisense oligonucleotide (AON) approach for Duchenne Muscular Dystrophy (DMD).

Her first work is published in the special exon skipping edition of the journal Nucleic acid therapeutics February 2014. And in 2013 she received a poster award at the Oligonucleotide Therapeutic Society (OTS) meeting in Italy Napels 2013.

Click here to see the publication list of Silvana Jirka

Group members

Margriet Hulsker, BASc.

Margriet Hulsker is a Research Technician in the DMD Genetic Therapy Group since May 2010. Her project involves quantification of dystrophin levels in mouse tissues by different techniques like western blotting, imunostaining and PCR.
Futhermore, the optimalisation of the Western blotting technique is high priority in her work and will hopefully result in a paper publication.

Click here to see the publication list of Margriet Hulsker

Group members

Isabella Houweling-Gazzoli, PhD

Dr. Isabella Houweling-Gazzoli is a postdoc researcher in the DMD Genetic Therapy Group since October 2009. She is currently involved in the transcriptome analysis of the DMD gene and in exploring AON-mediated exon skipping as a potential therapeutic approach for Dysferlinopathies. She previously worked for two different biotechnology companies (DSM Anti-Infectives, Delft and Genmab BV, Molecular Biology Unit, Utrecht). She also performed research at Ludwig Institute for Cancer Research, UCSD, La Jolla, CA, USA and received her Ph.D. degree in Molecular Genetics, Utrecht University (Promotors: Prof. Dr. Hans Clevers and Prof. Dr. Richard Kolodner).

Click here to see the publication list of dr. Isabella Houweling-Gazzoli