Dystrophin protein

Figure 1: Overview of dystrophin in muscle

The dystrophin protein connects the cytoskeleton of muscle fibers with its N-terminal actin-binding domain and the extra-cellular matrix via a cysteine-rich C-terminal domain that binds dystroglycan, which in turn is bound to laminin 2 (Figure 1). Between these two functional domain lies a large central domain that consists of 24 spectrin like repeats (Figure 2).

dystrophin detailed info
Figure 2: simplified image of the dystrophin protein